I've been using Nginx for a few years now and plan to do so for many more, but it wasn't an easy setup to get used to. In fact, I'm still getting bit by the differences between it and Apache, which I have much more experience with. The one difference that stands out the most to me is the
For the most part, Apache directives are matched in a top down manner with later directives overwriting earlier ones if duplicated. Nginx directives on the other hand seem to operate a little differently.